Shaping sound in space: the regulation of inner ear patterning | Zendy

Andrew K. Groves | Zendy; Donna M. Fekete | Zendy

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Shaping sound in space: the regulation of inner ear patterning

Author(s) -

Andrew K. Groves,

Donna M. Fekete

Publication year - 2011

Publication title -

development

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.15

H-Index - 36

eISSN - 1477-9129

pISSN - 0950-1991

DOI - 10.1242/dev.067074

Subject(s) - biology , inner ear , mechanosensitive channels , ectoderm , sensory system , anatomy , embryonic induction , otic vesicle , utricle , embryonic stem cell , microbiology and biotechnology , neuroscience , embryogenesis , embryo , ion channel , mesoderm , receptor , genetics , gene , in situ hybridization , gene expression

The inner ear is one of the most morphologically elaborate tissues in vertebrates, containing a group of mechanosensitive sensory organs that mediate hearing and balance. These organs are arranged precisely in space and contain intricately patterned sensory epithelia. Here, we review recent studies of inner ear development and patterning which reveal that multiple stages of ear development - ranging from its early induction from the embryonic ectoderm to the establishment of the three cardinal axes and the fine-grained arrangement of sensory cells - are orchestrated by gradients of signaling molecules.

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