Open AccessEvolutionary plasticity of segmentation clock networks
Author(s) -
Aurélie J. Krol,
Daniela Roellig,
MaryLee Dequéant,
Olivier Tassy,
Earl Glynn,
Gaye Hattem,
Arcady Mushegian,
Andrew C. Oates,
Olivier Pourquié
Publication year - 2011
Publication title -
development
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.754
H-Index - 325
eISSN - 1477-9129
pISSN - 0950-1991
DOI - 10.1242/dev.063834
Subject(s) - biology , zebrafish , mesoderm , paraxial mesoderm , vertebral column , evolutionary biology , genetics , vertebrate , wnt signaling pathway , transcription factor , lamprey , gene , segmentation , anatomy , transcriptome , gene regulatory network , homeobox , microbiology and biotechnology , embryonic stem cell , gene expression , artificial intelligence , fishery , computer science
The vertebral column is a conserved anatomical structure that defines the vertebrate phylum. The periodic or segmental pattern of the vertebral column is established early in development when the vertebral precursors, the somites, are rhythmically produced from presomitic mesoderm (PSM). This rhythmic activity is controlled by a segmentation clock that is associated with the periodic transcription of cyclic genes in the PSM. Comparison of the mouse, chicken and zebrafish PSM oscillatory transcriptomes revealed networks of 40 to 100 cyclic genes mostly involved in Notch, Wnt and FGF signaling pathways. However, despite this conserved signaling oscillation, the identity of individual cyclic genes mostly differed between the three species, indicating a surprising evolutionary plasticity of the segmentation networks.
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