Regulation of DNA replication during development | Zendy

Jared T. Nordman | Zendy; Terry L. OrrWeaver | Zendy

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Regulation of DNA replication during development

Author(s) -

Jared T. Nordman,

Terry L. OrrWeaver

Publication year - 2012

Publication title -

development

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.754

H-Index - 325

eISSN - 1477-9129

pISSN - 0950-1991

DOI - 10.1242/dev.061838

Subject(s) - biology , dna replication , control of chromosome duplication , dna replication factor cdt1 , pre replication complex , origin recognition complex , eukaryotic dna replication , licensing factor , semiconservative replication , genetics , dna , replication factor c , microbiology and biotechnology , replication timing , dna re replication

As development unfolds, DNA replication is not only coordinated with cell proliferation, but is regulated uniquely in specific cell types and organs. This differential regulation of DNA synthesis requires crosstalk between DNA replication and differentiation. This dynamic aspect of DNA replication is highlighted by the finding that the distribution of replication origins varies between differentiated cell types and changes with differentiation. Moreover, differential DNA replication in some cell types can lead to increases or decreases in gene copy number along chromosomes. This review highlights the recent advances and technologies that have provided us with new insights into the developmental regulation of DNA replication.

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