Dissecting the regulatory switches of development: lessons from enhancer evolution in Drosophila | Zendy

Matthew J. Borok | Zendy; Diana A. Tran | Zendy; Margaret C.W. Ho | Zendy; Robert A. Drewell | Zendy

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Dissecting the regulatory switches of development: lessons from enhancer evolution in Drosophila

Author(s) -

Matthew J. Borok,

Diana A. Tran,

Margaret C.W. Ho,

Robert A. Drewell

Publication year - 2009

Publication title -

development

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.754

H-Index - 325

eISSN - 1477-9129

pISSN - 0950-1991

DOI - 10.1242/dev.036160

Subject(s) - enhancer , biology , gene , transcription factor , genetics , regulatory sequence , regulation of gene expression , computational biology , transcription (linguistics) , enhancer rnas , microbiology and biotechnology , linguistics , philosophy

Cis-regulatory modules are non-protein-coding regions of DNA essential for the control of gene expression. One class of regulatory modules is embryonic enhancers, which drive gene expression during development as a result of transcription factor protein binding at the enhancer sequences. Recent comparative studies have begun to investigate the evolution of the sequence architecture within enhancers. These analyses are illuminating the way that developmental biologists think about enhancers by revealing their molecular mechanism of function.

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