The function of non-coding RNAs in genomic imprinting | Zendy

Martha V. Koerner | Zendy; Florian M. Pauler | Zendy; Ru Huang | Zendy; Denise P. Barlow | Zendy

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The function of non-coding RNAs in genomic imprinting

Author(s) -

Martha V. Koerner,

Florian M. Pauler,

Ru Huang,

Denise P. Barlow

Publication year - 2009

Publication title -

development

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.754

H-Index - 325

eISSN - 1477-9129

pISSN - 0950-1991

DOI - 10.1242/dev.030403

Subject(s) - biology , genomic imprinting , gene , genome , non coding rna , computational biology , imprinting (psychology) , genetics , function (biology) , regulation of gene expression , gene expression , long non coding rna , small nucleolar rna , rna , dna methylation

Non-coding RNAs (ncRNAs) that regulate gene expression in cis or in trans are a shared feature of prokaryotic and eukaryotic genomes. In mammals, cis-acting functions are associated with macro ncRNAs, which can be several hundred thousand nucleotides long. Imprinted ncRNAs are well-studied macro ncRNAs that have cis-regulatory effects on multiple flanking genes. Recent advances indicate that they employ different downstream mechanisms to regulate gene expression in embryonic and placental tissues. A better understanding of these downstream mechanisms will help to improve our general understanding of the function of ncRNAs throughout the genome.

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