The regulation of TGFβ signal transduction | Zendy

Aristidis Moustakas | Zendy; CarlHenrik Heldin | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

The regulation of TGFβ signal transduction

Author(s) -

Aristidis Moustakas,

CarlHenrik Heldin

Publication year - 2009

Publication title -

development

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.754

H-Index - 325

eISSN - 1477-9129

pISSN - 0950-1991

DOI - 10.1242/dev.030338

Subject(s) - biology , smad , signal transduction , microbiology and biotechnology , smad2 protein , r smad , phosphorylation , transcription factor , serine , kinase , protein serine threonine kinases , transforming growth factor beta , effector , transforming growth factor , genetics , protein kinase a , endoglin , gene , stem cell , cd34

Transforming growth factor beta (TGFbeta) pathways are implicated in metazoan development, adult homeostasis and disease. TGFbeta ligands signal via receptor serine/threonine kinases that phosphorylate, and activate, intracellular Smad effectors as well as other signaling proteins. Oligomeric Smad complexes associate with chromatin and regulate transcription, defining the biological response of a cell to TGFbeta family members. Signaling is modulated by negative-feedback regulation via inhibitory Smads. We review here the mechanisms of TGFbeta signal transduction in metazoans and emphasize events crucial for embryonic development.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research