Polycomb/Trithorax response elements and epigenetic memory of cell identity | Zendy

Leonie Ringrose | Zendy; Renato Paro | Zendy

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Polycomb/Trithorax response elements and epigenetic memory of cell identity

Author(s) -

Leonie Ringrose,

Renato Paro

Publication year - 2006

Publication title -

development

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.754

H-Index - 325

eISSN - 1477-9129

pISSN - 0950-1991

DOI - 10.1242/dev.02723

Subject(s) - biology , polycomb group proteins , epigenetics , genome , genetics , repressor , epigenome , gene , evolutionary biology , computational biology , dna methylation , transcription factor , gene expression

Polycomb/Trithorax group response elements (PRE/TREs) are fascinating chromosomal pieces. Just a few hundred base pairs long, these elements can remember and maintain the active or silent transcriptional state of their associated genes for many cell generations, long after the initial determining activators and repressors have disappeared. Recently, substantial progress has been made towards understanding the nuts and bolts of PRE/TRE function at the molecular level and in experimentally mapping PRE/TRE sites across whole genomes. Here we examine the insights, controversies and new questions that have been generated by this recent flood of data.

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