Chromatin and epigenetics in development: blending cellular memory with cell fate plasticity | Zendy

Giacomo Cavalli | Zendy

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Chromatin and epigenetics in development: blending cellular memory with cell fate plasticity

Author(s) -

Giacomo Cavalli

Publication year - 2006

Publication title -

development

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.754

H-Index - 325

eISSN - 1477-9129

pISSN - 0950-1991

DOI - 10.1242/dev.02402

Subject(s) - epigenetics , biology , chromatin , context (archaeology) , epigenesis , epigenomics , dna methylation , histone , cell fate determination , genetics , microbiology and biotechnology , dna , transcription factor , gene expression , gene , paleontology

The epigenetic regulation of chromatin structure and composition has often been studied molecularly in the context of specific DNA-dependent processes. However, epigenetics also play important global roles in shaping and maintaining cell identity, and in patterning the body plan during normal development. Moreover, alterations in epigenetic regulation are involved in many diseases, including cancer. The advances in our understanding of the impact of epigenetics in development and disease were discussed at a recent Keystone symposium.

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