Shaping BMP morphogen gradients in theDrosophilaembryo and pupal wing | Zendy

Michael B. O’Connor | Zendy; David M. Umulis | Zendy; Hans G. Othmer | Zendy; Seth S. Blair | Zendy

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Shaping BMP morphogen gradients in theDrosophilaembryo and pupal wing

Author(s) -

Michael B. O’Connor,

David M. Umulis,

Hans G. Othmer,

Seth S. Blair

Publication year - 2005

Publication title -

development

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.15

H-Index - 36

eISSN - 1477-9129

pISSN - 0950-1991

DOI - 10.1242/dev.02214

Subject(s) - biology , decapentaplegic , morphogen , ectoderm , wing , microbiology and biotechnology , bone morphogenetic protein , embryo , imaginal disc , drosophila (subgenus) , cell fate determination , drosophila melanogaster , signal transduction , mesoderm , anatomy , embryogenesis , genetics , transcription factor , embryonic stem cell , gene , aerospace engineering , engineering

In the early Drosophila embryo, BMP-type ligands act as morphogens to suppress neural induction and to specify the formation of dorsal ectoderm and amnioserosa. Likewise, during pupal wing development, BMPs help to specify vein versus intervein cell fate. Here, we review recent data suggesting that these two processes use a related set of extracellular factors, positive feedback, and BMP heterodimer formation to achieve peak levels of signaling in spatially restricted patterns. Because these signaling pathway components are all conserved, these observations should shed light on how BMP signaling is modulated in vertebrate development.

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