Neural stem cells: balancing self-renewal with differentiation | Zendy

Chris Q. Doe | Zendy

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Neural stem cells: balancing self-renewal with differentiation

Author(s) -

Chris Q. Doe

Publication year - 2008

Publication title -

development

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.754

H-Index - 325

eISSN - 1477-9129

pISSN - 0950-1991

DOI - 10.1242/dev.014977

Subject(s) - biology , stem cell , neural stem cell , progenitor cell , cellular differentiation , microbiology and biotechnology , neurosphere , adult stem cell , progenitor , cancer stem cell , neuroscience , genetics , gene

Stem cells are captivating because they have the potential to make multiple cell types yet maintain their undifferentiated state. Recent studies of Drosophila and mammalian neural stem cells have shed light on how stem cells regulate self-renewal versus differentiation and have revealed the proteins, processes and pathways that all converge to regulate neural progenitor self-renewal. If we can better understand how stem cells balance self-renewal versus differentiation, we will significantly advance our knowledge of embryogenesis, cancer biology and brain evolution, as well as the use of stem cells for therapeutic purposes.

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