From placode to polarization: new tunes in inner ear development | Zendy

Kate F. Barald | Zendy; Matthew W. Kelley | Zendy

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From placode to polarization: new tunes in inner ear development

Author(s) -

Kate F. Barald,

Matthew W. Kelley

Publication year - 2004

Publication title -

development

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.754

H-Index - 325

eISSN - 1477-9129

pISSN - 0950-1991

DOI - 10.1242/dev.01339

Subject(s) - biology , inner ear , neuroscience , convergent extension , morphogenesis , vertebrate , hair cell , anatomy , microbiology and biotechnology , embryogenesis , genetics , gastrulation , embryo , gene

The highly orchestrated processes that generate the vertebrate inner ear from the otic placode provide an excellent and circumscribed testing ground for fundamental cellular and molecular mechanisms of development. The recent pace of discovery in developmental auditory biology has been unusually rapid, with hundreds of papers published in the past 4 years. This review summarizes studies addressing several key issues that shape our current thinking about inner ear development, with particular emphasis on early patterning events, sensory hair cell specification and planar cell polarity.

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