Roles of theC. eleganscyclophilin-like protein MOG-6 in MEP-1 binding and germline fates | Zendy

Marco Belfiore | Zendy; Paolo Pugnale | Zendy; Zarifja Saudan | Zendy; Alessandro Puoti | Zendy

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Roles of theC. eleganscyclophilin-like protein MOG-6 in MEP-1 binding and germline fates

Author(s) -

Marco Belfiore,

Paolo Pugnale,

Zarifja Saudan,

Alessandro Puoti

Publication year - 2004

Publication title -

development

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.754

H-Index - 325

eISSN - 1477-9129

pISSN - 0950-1991

DOI - 10.1242/dev.01154

Subject(s) - biology , caenorhabditis elegans , germline , genetics , microbiology and biotechnology , zinc finger , oocyte , nuclear receptor , oogenesis , cyclophilin , gene , transcription factor , embryo

The switch from spermatogenesis to oogenesis in the Caenorhabditis elegans hermaphrodite requires mog-6, which post-transcriptionally represses the fem-3 RNA. In this study, we show that mog-6 codes for a divergent nuclear cyclophilin, in that a conserved domain is not required for its function in the sperm-oocyte switch. MOG-6 binds to the nuclear zinc finger protein MEP-1 through two separate domains that are essential for the role of MOG-6 in the sperm-oocyte switch. We propose that MOG-6 has a function distinct from that of prevailing cyclophilins and that its binding to MEP-1 is essential for germline sex determination. Finally, we found that gld-3 mog-6 mutants develop germline tumors, suggesting that mog-6 might function in the decision between mitosis and meiosis.

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