Frizzled signalling and cell polarisation inDrosophilaand vertebrates | Zendy

David Strutt | Zendy

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Frizzled signalling and cell polarisation inDrosophilaand vertebrates

Author(s) -

David Strutt

Publication year - 2003

Publication title -

development

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.754

H-Index - 325

eISSN - 1477-9129

pISSN - 0950-1991

DOI - 10.1242/dev.00695

Subject(s) - frizzled , biology , signalling pathways , cell polarity , wnt signaling pathway , microbiology and biotechnology , hedgehog signaling pathway , signalling , genetic screen , drosophila (subgenus) , cell , signal transduction , computational biology , genetics , gene , phenotype

A key aspect of animal development is the appropriate polarisation of different cell types in the right place at the right time. Such polarisation is often precisely coordinated relative to the axes of a tissue or organ, but the mechanisms underlying this coordination are still poorly understood. Nevertheless, genetic analysis of animal development has revealed some of the pathways involved. For example, a non-canonical Frizzled signalling pathway has been found to coordinate cell polarity throughout the insect cuticle, and recent work has implicated an analogous pathway in coordinated polarisation of cells during vertebrate development. This review discusses recent findings regarding non-canonical Frizzled signalling and cell polarisation.

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