Distinct roles of transcription factors EGL-46 and DAF-19 in specifying the functionality of a polycystin-expressing sensory neuron necessary forC. elegansmale vulva location behavior | Zendy

Hui Yu | Zendy; René F. Prétôt | Zendy; Thomas R. Bürglin | Zendy; Paul W. Sternberg | Zendy

Open Access

Distinct roles of transcription factors EGL-46 and DAF-19 in specifying the functionality of a polycystin-expressing sensory neuron necessary forC. elegansmale vulva location behavior

Author(s) -

Hui Yu,

René F. Prétôt,

Thomas R. Bürglin,

Paul W. Sternberg

Publication year - 2003

Publication title -

development

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.754

H-Index - 325

eISSN - 1477-9129

pISSN - 0950-1991

DOI - 10.1242/dev.00678

Subject(s) - biology , caenorhabditis elegans , hermaphrodite , sensory system , transcription factor , regulator , sensory neuron , neuron , microbiology and biotechnology , transcription (linguistics) , genetics , gene , neuroscience , ecology , linguistics , philosophy

Caenorhabditis elegans polycystins LOV-1 and PKD-2 are expressed in the male-specific HOB neuron, and are necessary for sensation of the hermaphrodite vulva during mating. We demonstrate that male vulva location behavior and expression of lov-1 and pkd-2 in the ciliated sensory neuron HOB require the activities of transcription factor EGL-46 and to some extent also EGL-44. This EGL-46- regulated program is specific to HOB and is distinct from a general ciliogenic pathway functioning in all ciliated neurons. The ciliogenic pathway regulator DAF-19 affects downstream components of the HOB-specific program indirectly and is independent of EGL-46 activity. The sensory function of HOB requires the combined action of these two distinct regulatory pathways.

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