Islet1 cardiovascular progenitors: a single source for heart lineages? | Zendy

KarlLudwig Laugwitz | Zendy; Alessandra Moretti | Zendy; Leslie Caron | Zendy; Atsushi Nakano | Zendy; Kenneth R. Chien | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Islet1 cardiovascular progenitors: a single source for heart lineages?

Author(s) -

KarlLudwig Laugwitz,

Alessandra Moretti,

Leslie Caron,

Atsushi Nakano,

Kenneth R. Chien

Publication year - 2007

Publication title -

development

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.754

H-Index - 325

eISSN - 1477-9129

pISSN - 0950-1991

DOI - 10.1242/dev.001883

Subject(s) - biology , embryonic stem cell , progenitor cell , stem cell , cellular differentiation , microbiology and biotechnology , lineage (genetic) , myocyte , cell type , multipotent stem cell , progenitor , haematopoiesis , genetics , immunology , cell , gene

The creation of regenerative stem cell therapies for heart disease requires that we understand the molecular mechanisms that govern the fates and differentiation of the diverse muscle and non-muscle cell lineages of the heart. Recently, different cardiac cell types have been reported to arise from a common, multipotent Islet1 (Isl1)-positive progenitor, suggesting that a clonal model of heart lineage diversification might occur that is analogous to hematopoiesis. The ability to isolate, renew and differentiate Isl1(+) precursors from postnatal and embryonic hearts and from embryonic stem cells provides a powerful cell-based system for characterizing the signaling pathways that control cardiovascular progenitor formation, renewal, lineage specification and conversion to specific differentiated progeny.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research