CBX7 gene expression plays a negative role in adipocyte cell growth and differentiation | Zendy

Floriana Forzati | Zendy; Antonella Federico | Zendy; Pierlorenzo Pallante | Zendy; Marianna Colamaio | Zendy; Francesco Esposito | Zendy; Romina Sepe | Zendy; Sara Gargiulo | Zendy; Antonio Luciano | Zendy; Claudio Arra | Zendy; Giuseppe Palma | Zendy; Giulia Bon | Zendy; S. Bucher | Zendy; Rita Falcioni | Zendy; Arturo Brunetti | Zendy; Sabrina Battista | Zendy; Monica Fedele | Zendy; Alfredo Fusco | Zendy

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CBX7 gene expression plays a negative role in adipocyte cell growth and differentiation

Author(s) -

Floriana Forzati,

Antonella Federico,

Pierlorenzo Pallante,

Marianna Colamaio,

Francesco Esposito,

Romina Sepe,

Sara Gargiulo,

Antonio Luciano,

Claudio Arra,

Giuseppe Palma,

Giulia Bon,

S. Bucher,

Rita Falcioni,

Arturo Brunetti,

Sabrina Battista,

Monica Fedele,

Alfredo Fusco

Publication year - 2014

Publication title -

biology open

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.936

H-Index - 41

ISSN - 2046-6390

DOI - 10.1242/bio.20147872

Subject(s) - biology , adipogenesis , embryonic stem cell , phenotype , downregulation and upregulation , adipocyte , knockout mouse , adipose tissue , microbiology and biotechnology , null cell , suppressor , cellular differentiation , cancer research , gene , genetics , endocrinology

We have recently generated knockout mice for the Cbx7 gene, coding for a polycomb group protein that is downregulated in human malignant neoplasias. These mice develop liver and lung adenomas and carcinomas, which confirms a tumour suppressor role for CBX7. The CBX7 ability to downregulate CCNE1 expression likely accounts for the phenotype of the Cbx7-null mice. Unexpectedly, Cbx7-knockout mice had a higher fat tissue mass than wild-type, suggesting a role of CBX7 in adipogenesis. Consistently, we demonstrate that Cbx7-null mouse embryonic fibroblasts go towards adipocyte differentiation more efficiently than their wild-type counterparts, and this effect is Cbx7 dose-dependent. Similar results were obtained when Cbx7-null embryonic stem cells were induced to differentiate into adipocytes. Conversely, mouse embryonic fibroblasts and human adipose-derived stem cells overexpressing CBX7 show an opposite behaviour. These findings support a negative role of CBX7 in the control of adipocyte cell growth and differentiation.

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