English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

In recent years, the clinical significance of  Aerococcus urinae  has been increasingly recognized.  A. urinae  has been implicated in cases of urinary tract infection (UTI; acute cystitis and pyelonephritis) in both male and female patients, ranging from children to older adults.  Aerococcus urinae  can also be invasive, causing urosepsis, endocarditis, and musculoskeletal infections. Mechanisms of pathogenesis in  A. urinae  infections are poorly understood, largely due to the lack of an animal model system. In response to this gap, we developed a model of  A. urinae  urinary tract infection in mice. We compared  A. urinae  UTI in female C3H/HeN and C57BL/6 mice and compared four clinical isolates of  A. urinae  isolated from patients with UTI, urgency urinary incontinence, and overactive bladder. Our data demonstrate that host genetic background modulates  A. urinae  UTI. Female C57BL/6 female mice rapidly cleared the infection. Female C3H/HeN mice, which have inherent vesicoureteral reflux that flushes urine from the bladder up into the kidneys, were susceptible to prolonged bacteriuria. This result is consistent with the fact that  A. urinae  infections most frequently occur in patients with underlying urinary tract abnormalities or disorders that make them susceptible to bacterial infection. Unlike uropathogens such as  E. coli , which cause infection and inflammation both of the bladder and kidneys in C3H/HeN mice,  A. urinae  displayed tropism for the kidney, persisting in kidney tissue even after clearance of bacteria from the bladder.  Aerococcus urinae  strains from different genetic clades displayed varying propensities to cause persistent kidney infection.  Aerococcus urinae  infected kidneys displayed histological inflammation, neutrophil recruitment and increased pro-inflammatory cytokines. These results set the stage for future research that interrogates host-pathogen interactions between  A. urinae  and the urinary tract.

A mouse model displays host and bacterial strain differences in Aerococcus urinae urinary tract infection