MonitoringSchizosaccharomyces pombegenome stress by visualizing end-binding protein Ku | Zendy

Chance E. Jones | Zendy; Susan L. Forsburg | Zendy

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MonitoringSchizosaccharomyces pombegenome stress by visualizing end-binding protein Ku

Author(s) -

Chance E. Jones,

Susan L. Forsburg

Publication year - 2021

Publication title -

biology open

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.936

H-Index - 41

ISSN - 2046-6390

DOI - 10.1242/bio.054346

Subject(s) - schizosaccharomyces pombe , biology , schizosaccharomyces , computational biology , genome , genetics , bioinformatics , microbiology and biotechnology , gene , saccharomyces cerevisiae

Studies of genome stability have exploited visualization of fluorescently tagged proteins in live cells to characterize DNA damage, checkpoint, and repair responses. In this report, we describe a new tool for fission yeast, a tagged version of the end-binding protein Pku70 which is part of the KU protein complex. We compare Pku70 localization to other markers upon treatment to various genotoxins, and identify a unique pattern of distribution. Pku70 provides a new tool to define and characterize DNA lesions and the repair response.

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