Effects of chronic inhibition of Testosterone metabolism on cardiac remodeling after ischemia/reperfusion-induced myocardial damage in gonadectomized rats | Zendy

Octavio Maldonado | Zendy; Ángel Ramos-Ligonio | Zendy; Mario R.B. GuapilloVargas | Zendy; José María Rivera | Zendy; Ícela Palma-Lara | Zendy; Iván Rubio-Gayosso | Zendy; Israel RamírezSánchez | Zendy; Nayelli Nájera | Zendy; Guillermo Ceballos | Zendy; Enrique Méndez-Bolaina | Zendy

Open Access

Effects of chronic inhibition of Testosterone metabolism on cardiac remodeling after ischemia/reperfusion-induced myocardial damage in gonadectomized rats

Author(s) -

Octavio Maldonado,

Ángel Ramos-Ligonio,

Mario R.B. GuapilloVargas,

José María Rivera,

Ícela Palma-Lara,

Iván Rubio-Gayosso,

Israel RamírezSánchez,

Nayelli Nájera,

Guillermo Ceballos,

Enrique Méndez-Bolaina

Publication year - 2019

Publication title -

biology open

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.936

H-Index - 41

ISSN - 2046-6390

DOI - 10.1242/bio.041905

Subject(s) - testosterone (patch) , biology , myocardial ischemia , ventricular remodeling , ischemia , medicine , cardiology , metabolism , reperfusion injury , endocrinology , myocardial infarction

The effects of testosterone on cardiovascular homeostasis are still not well understood. The objective of this work was to evaluate the effects of testosterone in the absence or presence of inhibition of Aromatase (4-hydroxyandrostenedione) and/or 5α reductase (Finasteride) enzymatic activities on the myocardial remodeling 30 days after ischemia/reperfusion (I/R) injury in gonadectomized rats. Results showed that testosterone administration to ORX rats resulted in decreased myocardial damaged area, inflammatory infiltrates and reduced MMP-3 and 13 expressions. Interestingly, Finasteride administration resulted in a greater decrease in scar tissue, inflammatory infiltrates, along with a significant decrease in MMP-3 and 13 expressions. In contrast, 4-hydroxyandrostenedione administrations increased all parameters. Our results suggest that testosterone does not have a direct effect since simultaneous inhibition of aromatase and 5α-reductase did not induce significant changes in I/R induced myocardial injury.

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