Gelsolin regulates proliferation, apoptosis and invasion in NK/T-cell lymphoma cells | Zendy

Yanwei Guo | Zendy; Hongqiao Zhang | Zendy; Xin Xing | Zendy; Lijuan Wang | Zendy; Jian Zhang | Zendy; Lin Yan | Zendy; Xiaoke Zheng | Zendy; Mingzhi Zhang | Zendy

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Gelsolin regulates proliferation, apoptosis and invasion in NK/T-cell lymphoma cells

Author(s) -

Yanwei Guo,

Hongqiao Zhang,

Xin Xing,

Lijuan Wang,

Jian Zhang,

Lin Yan,

Xiaoke Zheng,

Mingzhi Zhang

Publication year - 2017

Publication title -

biology open

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.936

H-Index - 41

ISSN - 2046-6390

DOI - 10.1242/bio.027557

Subject(s) - gelsolin , pi3k/akt/mtor pathway , biology , cancer research , protein kinase b , apoptosis , cell growth , downregulation and upregulation , lymphoma , microbiology and biotechnology , cell , signal transduction , immunology , actin , genetics , gene

The expression of gelsolin (GSN) is abnormal in many cancers, including extranodal nasal-type natural killer/T-cell lymphoma (NKTCL). However, the biological function of GSN and its mechanism in NKTCL remain unclear. We found that GSN overexpression significantly suppressed cell proliferation, colony formation and invasion, and promoted apoptosis of natural killer (NK) cell line YTS. Moreover, the upregulation of GSN significantly decreased the levels of PI3K and p-Akt. Interestingly, blocking the PI3K/Akt signaling pathway significantly inhibited cell proliferation and invasion and promoted apoptosis of YTS cells. In conclusion, our findings indicate that GSN can suppress cell proliferation and invasion and promote apoptosis of YTS cells, and the PI3K/Akt signaling pathway is likely to be involved in this process.

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