The addition of a developmental factor, unc-62, to already long-lived worms increases lifespan and healthspan | Zendy

Dror Sagi | Zendy

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The addition of a developmental factor, unc-62, to already long-lived worms increases lifespan and healthspan

Author(s) -

Dror Sagi

Publication year - 2017

Publication title -

biology open

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.936

H-Index - 41

ISSN - 2046-6390

DOI - 10.1242/bio.027433

Subject(s) - biology , longevity , phenotype , strain (injury) , trait , transgene , genetically modified mouse , ageing , genetics , microbiology and biotechnology , evolutionary biology , gene , anatomy , computer science , programming language

Aging is a complex trait that is affected by multiple genetic pathways. A relatively unexplored approach is to manipulate multiple independent aging pathways simultaneously in order to observe their cumulative effect on lifespan. Here, we report the phenotypic characterization of a strain with changes in five aging pathways: (1) mitochondrial reactive oxygen species (ROS) production, (2) innate immunity, (3) stress response, (4) metabolic control and (5) developmental regulation in old age. The quintuply modified strain has a lifespan that is 160% longer than the transgenic control strain. Additionally, the quintuply modified strain maintains several physiological markers of aging for a longer time than the transgenic control. Our results support a modular approach as a general scheme to study how multiple pathways interact to achieve extreme longevity.

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