REV-ERBα regulates Fgf21 expression in the liver via hepatic nuclear factor 6 | Zendy

Rohit Chavan | Zendy; Nadia Preitner | Zendy; Takashi Okabe | Zendy; Laureen Mansencal Strittmatter | Zendy; Cheng Xu | Zendy; Jürgen A. Ripperger | Zendy; Nelly Pitteloud | Zendy; Urs Albrecht | Zendy

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REV-ERBα regulates Fgf21 expression in the liver via hepatic nuclear factor 6

Author(s) -

Rohit Chavan,

Nadia Preitner,

Takashi Okabe,

Laureen Mansencal Strittmatter,

Cheng Xu,

Jürgen A. Ripperger,

Nelly Pitteloud,

Urs Albrecht

Publication year - 2016

Publication title -

biology open

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.936

H-Index - 41

ISSN - 2046-6390

DOI - 10.1242/bio.021519

Subject(s) - fgf21 , biology , regulator , circadian clock , reproduction , microbiology and biotechnology , fibroblast growth factor , circadian rhythm , endocrinology , medicine , genetics , gene , receptor

The circadian clock contributes to the timing of many body functions including metabolism and reproduction. The hepatokine fibroblast growth factor 21 (FGF21) is a critical metabolic regulator involved in modulation of fertility. Here we show that lack of the clock component REV-ERBα elevates FGF21 levels in liver and plasma. At the molecular level, REV-ERBα modulates the expression of FGF21 via the liver-specific hepatic nuclear factor 6 (HNF6). We conclude that REV-ERBα regulates metabolism and reproduction, at least in part, via regulation of Fgf21.

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