Open AccessThe Hemodynamic Response to Dexmedetomidine Loading Dose in Children With and Without Pulmonary Hypertension
Author(s) -
Robert H. Friesen,
Christopher S. Nichols,
Mark Twite,
Kathryn A. Cardwell,
Zhaoxing Pan,
Biagio A. Pietra,
Shelley D. Miyamoto,
Scott R. Auerbach,
Jeffrey R. Darst,
D. Dunbar Ivy
Publication year - 2013
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.404
H-Index - 201
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/ane.0b013e3182a15aa6
Subject(s) - medicine , dexmedetomidine , hemodynamics , haemodynamic response , anesthesia , pulmonary hypertension , cardiology , blood pressure , heart rate , sedation
Dexmedetomidine, an α-2 receptor agonist, is widely used in children with cardiac disease. Significant hemodynamic responses, including systemic and pulmonary vasoconstriction, have been reported after dexmedetomidine administration. Our primary goal of this prospective, observational study was to quantify the effects of dexmedetomidine initial loading doses on mean pulmonary artery pressure (PAP) in children with and without pulmonary hypertension.