Open AccessPropofol Shares the Binding Site with Isoflurane and Sevoflurane on Leukocyte Function–Associated Antigen-1
Author(s) -
Koichi Yuki,
Weiming Bu,
Xi Jin,
Motomu Shimaoka,
Roderic G. Eckenhoff
Publication year - 2013
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.404
H-Index - 201
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/ane.0b013e3182a00ae0
Subject(s) - propofol , allosteric regulation , binding site , lymphocyte function associated antigen 1 , ligand (biochemistry) , biophysics , stereochemistry , medicine , cell adhesion molecule , biochemistry , chemistry , intercellular adhesion molecule 1 , biology , receptor , pharmacology , immunology
We previously demonstrated that propofol interacted with the leukocyte adhesion molecule leukocyte function-associated antigen-1 (LFA-1) and inhibited the production of interleukin-2 via LFA-1 in a dependent manner. However, the binding site(s) of propofol on LFA-1 remains unknown.