Propofol Shares the Binding Site with Isoflurane and Sevoflurane on Leukocyte Function–Associated Antigen-1 | Zendy

Koichi Yuki | Zendy; Weiming Bu | Zendy; Xi Jin | Zendy; Motomu Shimaoka | Zendy; Roderic G. Eckenhoff | Zendy

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Propofol Shares the Binding Site with Isoflurane and Sevoflurane on Leukocyte Function–Associated Antigen-1

Author(s) -

Koichi Yuki,

Weiming Bu,

Xi Jin,

Motomu Shimaoka,

Roderic G. Eckenhoff

Publication year - 2013

Publication title -

anesthesia and analgesia

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.404

H-Index - 201

eISSN - 1526-7598

pISSN - 0003-2999

DOI - 10.1213/ane.0b013e3182a00ae0

Subject(s) - propofol , allosteric regulation , binding site , lymphocyte function associated antigen 1 , ligand (biochemistry) , biophysics , stereochemistry , medicine , cell adhesion molecule , biochemistry , chemistry , intercellular adhesion molecule 1 , biology , receptor , pharmacology , immunology

We previously demonstrated that propofol interacted with the leukocyte adhesion molecule leukocyte function-associated antigen-1 (LFA-1) and inhibited the production of interleukin-2 via LFA-1 in a dependent manner. However, the binding site(s) of propofol on LFA-1 remains unknown.

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