Open AccessLocal Toxicity from Local Anesthetic Polymeric Microparticles
Author(s) -
J. Brian McAlvin,
Gally Reznor,
Sahadev Shankarappa,
Cristina Ştefănescu,
Daniel S. Kohane
Publication year - 2013
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.404
H-Index - 201
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/ane.0b013e31828174a7
Subject(s) - bupivacaine , lidocaine , local anesthetic , medicine , myotoxin , anesthesia , plga , sciatic nerve , pharmacology , chemistry , venom , biochemistry , in vitro , snake venom
Local tissue injury from sustained-release formulations for local anesthetics can be severe. There is considerable variability in reporting of that injury. We investigated the influence of the intrinsic myotoxicity of the encapsulated local anesthetic (lidocaine, low; bupivacaine, high) on tissue reaction in rats.