The Antinociceptive and Antihyperalgesic Effects of Topical Propofol on Dorsal Horn Neurons in the Rat | Zendy

Kenichi Takechi | Zendy; Mirela Iodi Carstens | Zendy; Amanda H. Klein | Zendy; E. Carstens | Zendy

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The Antinociceptive and Antihyperalgesic Effects of Topical Propofol on Dorsal Horn Neurons in the Rat

Author(s) -

Kenichi Takechi,

Mirela Iodi Carstens,

Amanda H. Klein,

E. Carstens

Publication year - 2013

Publication title -

anesthesia and analgesia

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.404

H-Index - 201

eISSN - 1526-7598

pISSN - 0003-2999

DOI - 10.1213/ane.0b013e31827f560d

Subject(s) - propofol , medicine , anesthesia , nociception , electrophysiology , noxious stimulus , reflex , nociceptor , pharmacology , receptor

Propofol (2,6-diisopropylphenol) is an IV anesthetic used for general anesthesia. Recent evidence suggests that propofol-anesthetized patients experience less postoperative pain, and that propofol has analgesic properties when applied topically. We presently investigated the antinociceptive effects of topical propofol using behavioral and single-unit electrophysiological methods in rats.

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