Open AccessThe Antinociceptive and Antihyperalgesic Effects of Topical Propofol on Dorsal Horn Neurons in the Rat
Author(s) -
Kenichi Takechi,
Mirela Iodi Carstens,
Amanda H. Klein,
Earl Carstens
Publication year - 2013
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.404
H-Index - 201
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/ane.0b013e31827f560d
Subject(s) - propofol , medicine , anesthesia , nociception , electrophysiology , noxious stimulus , reflex , nociceptor , pharmacology , receptor
Propofol (2,6-diisopropylphenol) is an IV anesthetic used for general anesthesia. Recent evidence suggests that propofol-anesthetized patients experience less postoperative pain, and that propofol has analgesic properties when applied topically. We presently investigated the antinociceptive effects of topical propofol using behavioral and single-unit electrophysiological methods in rats.