Open AccessMicroarray Analyses of Genes Regulated by Isoflurane Anesthesia In Vivo
Author(s) -
Scott D. Edmands,
Eva LaDow,
Alex R. Hall
Publication year - 2013
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.404
H-Index - 201
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/ane.0b013e31827b27b0
Subject(s) - isoflurane , anesthetic , gene , microarray , biology , gene expression , microarray analysis techniques , in vivo , ischemic preconditioning , bioinformatics , microbiology and biotechnology , pharmacology , medicine , genetics , anesthesia , ischemia
Although general anesthetics are recognized for their potential to render patients unconscious during surgery, exposure can also lead to long-term outcomes of both cellular damage and protection. As regards the latter, delayed anesthetic preconditioning is an evolutionarily conserved physiological response that has the potential for protecting against ischemic injury in a number of tissues. Although it is known that delayed preconditioning requires de novo protein synthesis, knowledge of anesthetic-regulated genes is incomplete. In this study, we used the conserved nature of preconditioning to analyze differentially regulated genes in 3 different rat tissues. We hypothesized that by selecting those genes regulated in multiple tissues, we could develop a focused list of gene candidates potentially involved in delayed anesthetic preconditioning.