Emerging Trends in Clinical Trial Design

Therefore, randomized trial methodology was initiated only 6 decades ago. As might be expected from such a young field, the pace of advancement remains high. In this editorial, we discuss 3 emerging trends in clinical trial design. The techniques we discuss may be helpful to investigators who are designing randomized trials. They may also be helpful to department leaders who need to allocate resources and guide junior investigators. And finally, an understanding of the methods will also enhance clinicians’ ability to critically read and understand studies on which practice decisions might be based.