Open AccessReceptor Specificity Defines Algogenic Properties of Propofol and Fospropofol
Author(s) -
Amol Patwardhan,
Rebecca M. Edelmayer,
Emil Annabi,
Theodore J. Price,
Phil Malan,
Gregory Dussor
Publication year - 2012
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.404
H-Index - 201
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/ane.0b013e318258b9db
Subject(s) - propofol , medicine , pharmacology , nociceptor , transient receptor potential channel , receptor , nociception
Propofol-evoked injection site pain is not observed with fospropofol. We hypothesized that unlike propofol, fospropofol does not activate the irritant receptor, transient receptor potential 1 (TRPA1).