The Frequency and Magnitude of Cerebrospinal Fluid Pulsations Influence Intrathecal Drug Distribution | Zendy

Ying Hsu | Zendy; Hiroshan Hettiarachchi | Zendy; David C. Zhu | Zendy; Andreas A. Linninger | Zendy

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The Frequency and Magnitude of Cerebrospinal Fluid Pulsations Influence Intrathecal Drug Distribution

Author(s) -

Ying Hsu,

Hiroshan Hettiarachchi,

David C. Zhu,

Andreas A. Linninger

Publication year - 2012

Publication title -

anesthesia and analgesia

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.404

H-Index - 201

eISSN - 1526-7598

pISSN - 0003-2999

DOI - 10.1213/ane.0b013e3182536211

Subject(s) - medicine , cerebrospinal fluid , pulsatile flow , magnetic resonance imaging , anesthesia , stroke (engine) , stroke volume , drug , bolus (digestion) , volume of distribution , distribution (mathematics) , drug delivery , cardiology , heart rate , pharmacokinetics , pharmacology , radiology , blood pressure , mechanical engineering , mathematical analysis , chemistry , mathematics , organic chemistry , engineering

Intrathecal drug delivery is an efficient method to administer therapeutic molecules to the central nervous system. However, even with identical drug dosage and administration mode, the extent of drug distribution in vivo is highly variable and difficult to control. Different cerebrospinal fluid (CSF) pulsatility from patient to patient may lead to different drug distribution. Medical image-based computational fluid dynamics (miCFD) is used to construct a patient-specific model to quantify drug transport as a function of a spectrum of physiological CSF pulsations.

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