Open AccessIntrathecal Clonidine in the Neonatal Rat
Author(s) -
Suellen M. Walker,
Marjorie R. Grafe,
Tony L. Yaksh
Publication year - 2012
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.404
H-Index - 201
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/ane.0b013e3182501a09
Subject(s) - medicine , clonidine , spinal cord , anesthesia , histopathology , lumbar spinal cord , toxicity , pathology , psychiatry
Neuraxial clonidine is used for perioperative analgesia in children of all ages. Preclinical studies in the postnatal rat allow comparison of the relative toxicity and safety of spinal analgesics throughout postnatal development.