Open AccessDelayed Treatment with Lidocaine Reduces Mouse Microglial Cell Injury and Cytokine Production After Stimulation with Lipopolysaccharide and Interferon γ
Author(s) -
Hae-Jeong Jeong,
Dagui Lin,
Liaoliao Li,
Zhiyi Zuo
Publication year - 2012
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.404
H-Index - 201
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/ane.0b013e3182460ab5
Subject(s) - lipopolysaccharide , lidocaine , medicine , neuroinflammation , microglia , cytokine , pharmacology , stimulation , immunology , inflammation , anesthesia , endocrinology
Neuroinflammation is an important pathological process for almost all acquired neurological diseases. Microglial cells play a critical role in neuroinflammation. We determined whether lidocaine, a local anesthetic with anti-inflammatory property, protected microglial cells and attenuated cytokine production from activated microglial cells.