Delayed Treatment with Lidocaine Reduces Mouse Microglial Cell Injury and Cytokine Production After Stimulation with Lipopolysaccharide and Interferon γ | Zendy

Hae-Jeong Jeong | Zendy; Daowei Lin | Zendy; Liaoliao Li | Zendy; Zhiyi Zuo | Zendy

Open Access

Delayed Treatment with Lidocaine Reduces Mouse Microglial Cell Injury and Cytokine Production After Stimulation with Lipopolysaccharide and Interferon γ

Author(s) -

Hae-Jeong Jeong,

Daowei Lin,

Liaoliao Li,

Zhiyi Zuo

Publication year - 2012

Publication title -

anesthesia and analgesia

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.404

H-Index - 201

eISSN - 1526-7598

pISSN - 0003-2999

DOI - 10.1213/ane.0b013e3182460ab5

Subject(s) - lipopolysaccharide , lidocaine , medicine , neuroinflammation , microglia , cytokine , pharmacology , stimulation , immunology , inflammation , anesthesia , endocrinology

Neuroinflammation is an important pathological process for almost all acquired neurological diseases. Microglial cells play a critical role in neuroinflammation. We determined whether lidocaine, a local anesthetic with anti-inflammatory property, protected microglial cells and attenuated cytokine production from activated microglial cells.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research