Open AccessIsoflurane Posttreatment Reduces Brain Injury After an Intracerebral Hemorrhagic Stroke in Mice
Author(s) -
Nikan H. Khatibi,
Qingyi Ma,
William Rolland,
Robert P. Ostrowski,
Nancy Fathali,
Robert Martin,
Richard L. Applegate,
Gary Stier,
Jiping Tang,
Junyi Zhang
Publication year - 2011
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.404
H-Index - 201
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/ane.0b013e31821f9524
Subject(s) - isoflurane , medicine , anesthesia , stroke (engine) , intracerebral hemorrhage , tunel assay , basal ganglia , pathology , central nervous system , subarachnoid hemorrhage , immunohistochemistry , mechanical engineering , engineering
Intracerebral hemorrhage (ICH) is a devastating stroke subtype affecting 120,000 Americans annually. Of those affected, 40%to 50% will die within the first 30 days, whereas the survivors are left with a lifetime of neurobehavioral disabilities. Recently, it has been shown that volatile anesthetics such as isoflurane can reduce brain injury after an ischemic stroke. As a result, in this study, we investigated the effects of isoflurane as a posttreatment therapeutic modality in ICH-injured mice. Specifically, we investigated whether isoflurane posttreatment can preserve the structural integrity of the brain by reducing apoptotic damage and, in turn, improve functional outcome by amelioration of brain edema and neurobehavioral deficits.