Intrathecal Etanercept Partially Restores Morphine's Antinociception in Morphine-Tolerant Rats via Attenuation of the Glutamatergic Transmission | Zendy

ChingHui Shen | Zendy; RuYin Tsai | Zendy; Yueh-Hwa Tai | Zendy; ShinnLong Lin | Zendy; ChihCheng Chien | Zendy; ChihShung Wong | Zendy

Open Access

Intrathecal Etanercept Partially Restores Morphine's Antinociception in Morphine-Tolerant Rats via Attenuation of the Glutamatergic Transmission

Author(s) -

ChingHui Shen,

RuYin Tsai,

Yueh-Hwa Tai,

ShinnLong Lin,

ChihCheng Chien,

ChihShung Wong

Publication year - 2011

Publication title -

anesthesia and analgesia

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.404

H-Index - 201

eISSN - 1526-7598

pISSN - 0003-2999

DOI - 10.1213/ane.0b013e318217f7eb

Subject(s) - morphine , medicine , pharmacology , nociception , glutamatergic , opioid , etanercept , analgesic , hyperalgesia , opioid receptor , glutamate receptor , receptor , anesthesia , tumor necrosis factor alpha

Long-term exposure to morphine leads to analgesic tolerance. In addition to an opioid receptor conformational change, enhancing the glutamatergic signal transmission is also involved in morphine tolerance. Tumor necrosis factor-α has been demonstrated to correlate with neuronal plasticity via activation of glutamatergic transmission. We examined the effect of etanercept, a tumor necrosis factor-α inhibitor on morphine tolerance in rats.

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