Open AccessThe Effects of Neuropeptide S on General Anesthesia in Rats
Author(s) -
Tetsuya Kushikata,
Hitoshi Yoshida,
M Kudo,
Severo Salvadori,
Girolamo Calò,
Kazuyoshi Hirota
Publication year - 2011
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.404
H-Index - 201
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/ane.0b013e31820b990d
Subject(s) - medicine , neuropeptide , ketamine , anesthesia , antagonist , wakefulness , endocrinology , receptor , electroencephalography , psychiatry
Neuropeptide S (NPS) and its receptor (NPSR) is a novel neuropeptide system that regulates arousal and anxiety. A link between natural sleep and general anesthesia has been suggested. Therefore, we hypothesized that the NPS neuronal system may also modulate general anesthesia.