Enhanced Thrombin Generation After Cardiopulmonary Bypass Surgery | Zendy

Susanne Lison | Zendy; Wulf Dietrich | Zendy; Siegmund Braun | Zendy; Johannes Boehm | Zendy; Tibor Schuster | Zendy; Anna S. Englhard | Zendy; Anna Maria Perchuć | Zendy; Michael Spannagl | Zendy; Raimund Busley | Zendy

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Enhanced Thrombin Generation After Cardiopulmonary Bypass Surgery

Author(s) -

Susanne Lison,

Wulf Dietrich,

Siegmund Braun,

Johannes Boehm,

Tibor Schuster,

Anna S. Englhard,

Anna Maria Perchuć,

Michael Spannagl,

Raimund Busley

Publication year - 2010

Publication title -

anesthesia and analgesia

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.404

H-Index - 201

eISSN - 1526-7598

pISSN - 0003-2999

DOI - 10.1213/ane.0b013e3181fc6df0

Subject(s) - medicine , thrombin , hemostasis , cardiopulmonary bypass , anesthesia , cardiac surgery , cardiology , troponin t , surgery , myocardial infarction , platelet

Thrombin generation has a key role in the pathophysiology of hemostasis. Research has focused on the intraoperative course of hemostasis, while little is known about postoperative hemostatic activation. Thrombin generation assays quantify the potential for thrombin generation ex vivo and may be useful for determining hypercoagulability. The thrombin dynamics test (TDT) assesses the initial kinetics of thrombin formation. We hypothesized that there would be an increase in thrombin generation as well as thrombin capacity after cardiac surgery.

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