Nimodipine Prevents Memory Impairment Caused by Nitroglycerin-Induced Hypotension in Adult Mice | Zendy

Alex Bekker | Zendy; Michael Haile | Zendy; Yong Sheng Li | Zendy; Samuel M. Galoyan | Zendy; Edwardo Garcia | Zendy; David Quartermain | Zendy; Angela R. Kamer | Zendy; Thomas J. J. Blanck | Zendy

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Nimodipine Prevents Memory Impairment Caused by Nitroglycerin-Induced Hypotension in Adult Mice

Author(s) -

Alex Bekker,

Michael Haile,

Yong Sheng Li,

Samuel M. Galoyan,

Edwardo Garcia,

David Quartermain,

Angela R. Kamer,

Thomas J. J. Blanck

Publication year - 2009

Publication title -

anesthesia and analgesia

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.404

H-Index - 201

eISSN - 1526-7598

pISSN - 0003-2999

DOI - 10.1213/ane.0b013e3181beeb3b

Subject(s) - nimodipine , medicine , anesthesia , cerebral blood flow , saline , analysis of variance , blood pressure , hemodynamics , mean arterial pressure , heart rate , calcium

Hypotension and a resultant decrease in cerebral blood flow have been implicated in the development of cognitive dysfunction. We tested the hypothesis that nimodipine (NIMO) administered at the onset of nitroglycerin (NTG)-induced hypotension would preserve long-term associative memory.

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