Open AccessNimodipine Prevents Memory Impairment Caused by Nitroglycerin-Induced Hypotension in Adult Mice
Author(s) -
Alex Bekker,
Michael Haile,
Yong Sheng Li,
Samuel M. Galoyan,
Edwardo Garcia,
David Quartermain,
Angela R. Kamer,
Thomas J. J. Blanck
Publication year - 2009
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.404
H-Index - 201
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/ane.0b013e3181beeb3b
Subject(s) - nimodipine , medicine , anesthesia , cerebral blood flow , saline , analysis of variance , blood pressure , hemodynamics , mean arterial pressure , heart rate , calcium
Hypotension and a resultant decrease in cerebral blood flow have been implicated in the development of cognitive dysfunction. We tested the hypothesis that nimodipine (NIMO) administered at the onset of nitroglycerin (NTG)-induced hypotension would preserve long-term associative memory.