Open AccessAcute Methadone Treatment Reduces Myocardial Infarct Size via the δ-Opioid Receptor in Rats During Reperfusion
Author(s) -
Eric R. Gross,
Anna Hsu,
Garrett J. Gross
Publication year - 2009
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.404
H-Index - 201
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/ane.0b013e3181b92201
Subject(s) - medicine , methadone , naltrindole , anesthesia , morphine , ischemia , opioid , agonist , placebo , myocardial infarction , coronary occlusion , opioid receptor , pharmacology , cardiology , receptor , alternative medicine , pathology
Methadone is an opioid agonist often given to manage acute and chronic pain. We sought to determine whether methadone compared with morphine dose dependently reduces myocardial infarct size (IS) and whether the mechanism is delta-opioid receptor mediated. Furthermore, we examined whether myocardial IS reduction varies with the timing of methadone administration or duration of induced ischemia.