Acute Methadone Treatment Reduces Myocardial Infarct Size via the δ-Opioid Receptor in Rats During Reperfusion | Zendy

Eric R. Gross | Zendy; Anna K. Hsu | Zendy; Garrett J. Gross | Zendy

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Acute Methadone Treatment Reduces Myocardial Infarct Size via the δ-Opioid Receptor in Rats During Reperfusion

Author(s) -

Eric R. Gross,

Anna K. Hsu,

Garrett J. Gross

Publication year - 2009

Publication title -

anesthesia and analgesia

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.404

H-Index - 201

eISSN - 1526-7598

pISSN - 0003-2999

DOI - 10.1213/ane.0b013e3181b92201

Subject(s) - medicine , methadone , myocardial infarction , cardiology , anesthesia , opioid , reperfusion injury , receptor , ischemia

Methadone is an opioid agonist often given to manage acute and chronic pain. We sought to determine whether methadone compared with morphine dose dependently reduces myocardial infarct size (IS) and whether the mechanism is delta-opioid receptor mediated. Furthermore, we examined whether myocardial IS reduction varies with the timing of methadone administration or duration of induced ischemia.

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