Open AccessResponse Surface Model Predictions of Emergence and Response to Pain in the Recovery Room
Author(s) -
Noah Syroid,
Ken B. Johnson,
Nathan L. Pace,
Dwayne R. Westenskow,
Diane O. Tyler,
Frederike Brühschwein,
Robert Albert,
Shelly Roalstad,
Samuel Costy-Bennett,
Talmage D. Egan
Publication year - 2010
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.404
H-Index - 201
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/ane.0b013e3181b11289
Subject(s) - fentanyl , remifentanil , sevoflurane , isoflurane , medicine , anesthesia , anesthetic , noxious stimulus , propofol , nociception , receptor
Sevoflurane-remifentanil interaction models that predict responsiveness and response to painful stimuli have been evaluated in patients undergoing elective surgery. Preliminary evaluations of model predictions were found to be consistent with observations in patients anesthetized with sevoflurane, remifentanil, and fentanyl. This study explored the feasibility of adapting the predictions of sevoflurane-remifentanil interaction models to an isoflurane-fentanyl anesthetic. We hypothesized that model predictions adapted for isoflurane and fentanyl are consistent with observed patient responses and are similar to the predictions observed in our previous work with sevoflurane-remifentanil/fentanyl anesthetics.