Open AccessCytokine Gene Expression After Total Hip Arthroplasty: Surgical Site versus Circulating Neutrophil Response
Author(s) -
Asokumar Buvanendran,
Kendall Mitchell,
Jeffrey S. Kroin,
Michael J. Iadarola
Publication year - 2009
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.404
H-Index - 201
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/ane.0b013e3181ac1746
Subject(s) - chemokine , medicine , macrophage inflammatory protein , interleukin 8 , immunology , inflammation , cytokine , interleukin 1 receptor antagonist , proinflammatory cytokine , interleukin , gene expression , macrophage migration inhibitory factor , receptor , receptor antagonist , gene , biology , antagonist , biochemistry
After surgery, cytokines and chemokines are released at the surgical wound site, which can contribute to postoperative pain, local inflammation, and tissue repair. Multiple cell types are present that can release cytokines/chemokines at the wound site and, thus, the exact cellular source of these molecules is unclear. We sought to better understand the contribution of neutrophils to cytokine/chemokine gene expression at the surgical wound site during the initial postsurgery phase of total hip arthroplasty (THA).