Open AccessLidocaine Injection into the Rat Dorsal Root Ganglion Causes Neuroinflammation
Author(s) -
Livia Puljak,
Sanja Lovrić Kojundžić,
Quinn H. Hogan,
Damir Sapunar
Publication year - 2009
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.404
H-Index - 201
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/ane.0b013e318193873e
Subject(s) - medicine , lidocaine , dorsal root ganglion , neuroinflammation , anesthesia , dorsum , neuroscience , anatomy , inflammation , biology
Injury of a spinal nerve or dorsal root ganglion (DRG) during selective spinal nerve blocks is a potentially serious complication that has not been adequately investigated. Our hypothesis was that local anesthetic injection into these structures may result in an inflammatory response and hyperalgesia.