Open AccessThe Effect of Intravenous Lidocaine on Brain Activation During Non-Noxious and Acute Noxious Stimulation of the Forepaw: A Functional Magnetic Resonance Imaging Study in the Rat
Author(s) -
Zhongchi Luo,
Mei Yu,
Shane Smith,
Mary F. Kritzer,
Congwu Du,
Yu Ma,
Nora D. Volkow,
Peter S. A. Glass,
Helene Benveniste
Publication year - 2009
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.404
H-Index - 201
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/ane.0b013e31818e0d34
Subject(s) - medicine , lidocaine , noxious stimulus , stimulation , anesthesia , functional magnetic resonance imaging , somatosensory system , nociception , neuroscience , analgesic , psychology , receptor , psychiatry , radiology
Lidocaine can alleviate acute as well as chronic neuropathic pain at very low plasma concentrations in humans and laboratory animals. The mechanism(s) underlying lidocaine's analgesic effect when administered systemically is poorly understood but clearly not related to interruption of peripheral nerve conduction. Other targets for lidocaine's analgesic action(s) have been suggested, including sodium channels and other receptor sites in the central rather than peripheral nervous system. To our knowledge, the effect of lidocaine on the brain's functional response to pain has never been investigated. Here, we therefore characterized the effect of systemic lidocaine on the brain's response to innocuous and acute noxious stimulation in the rat using functional magnetic resonance imaging (fMRI).