Open AccessPostischemic Brain Injury Is Attenuated in Mice Lacking the β2-Adrenergic Receptor
Author(s) -
Ru Quan Han,
Yi Bing Ouyang,
Lijun Xu,
Rani Agrawal,
Andrew J. Patterson,
Rona G. Giffard
Publication year - 2009
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.404
H-Index - 201
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/ane.0b013e318187ba6b
Subject(s) - medicine , adrenergic , adrenergic receptor , receptor , anesthesia
Several beta-adrenergic receptor (betaAR) antagonists have been shown to have neuroprotective effects against cerebral ischemia. However, clenbuterol, a beta(2)AR agonist, was shown to have neuroprotective activity by increasing nerve growth factor expression. We used beta(2)AR knockout mice and a beta(2) selective antagonist to test the effect of loss of beta(2)ARs on outcome from transient focal cerebral ischemia.