Open AccessIn Vivo Exposure to High or Low Cortisol Has Biphasic Effects on Inflammatory Response Pathways of Human Monocytes
Author(s) -
Mark P. Yeager,
Patricia A. Pioli,
Kathleen Wardwell,
Michael L. Beach,
P Martel,
Hong K. Lee,
Athos J. Rassias,
Paul M. Guyre
Publication year - 2008
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.404
H-Index - 201
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/ane.0b013e3181875fb0
Subject(s) - medicine , in vivo , inflammatory response , monocyte , pharmacology , inflammation , immunology , genetics , biology
Recent studies demonstrate that glucocorticoids (GCs) have both supportive (stimulatory) and suppressive effects on immune responses, depending upon the GC concentration. Since some GC effects on inflammation are stimulatory, we hypothesized that acute in vivo GC depletion would decrease inflammatory responses of human monocytes.