Open AccessIncreases in Spinal Cerebrospinal Fluid Potassium Concentration Do Not Increase Isoflurane Minimum Alveolar Concentration in Rats
Author(s) -
Dimitry Shnayderman,
Michael J. Laster,
Edmond I. Eger,
Irene Oh,
Yi Zhang,
Steven L. Jinks,
Joseph F. Antognini,
Douglas E. Raines
Publication year - 2008
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.404
H-Index - 201
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/ane.0b013e3181815f2b
Subject(s) - isoflurane , medicine , minimum alveolar concentration , spinal cord , anesthesia , cerebrospinal fluid , potassium , inhalation , endocrinology , chemistry , organic chemistry , psychiatry
Previous studies demonstrated that MAC for isoflurane directly correlates with the concentration of Na(+) in cerebrospinal fluid surrounding the spinal cord, the primary site for mediation of the immobility produced by inhaled anesthetics. If this correlation resulted from increased irritability of the cord, then infusion of increased concentrations of potassium (K(+)) might be predicted to act similarly. However, an absence of effect of K(+) might be interpreted to indicate that K(+) channels do not mediate the immobility produced by inhaled anesthetics whereas Na(+) channels remain as potential mediators. Accordingly, in the present study, we examined the effect of altering intrathecal concentrations of K(+) on MAC.