Open AccessSynergy Between Pairs of Competitive Antagonists at Adult Human Muscle Acetylcholine Receptors
Author(s) -
Man Liu,
James P. Dilger
Publication year - 2008
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.404
H-Index - 201
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/ane.0b013e31817b4469
Subject(s) - medicine , competitive antagonist , antagonist , pharmacology , acetylcholine receptor , rocuronium , d tubocurarine , receptor , nicotinic agonist , acetylcholine , neuromuscular blocking agents , receptor antagonist , protein subunit , anesthesia , biochemistry , biology , propofol , gene
Synergistic neuromuscular blocking effects have been observed clinically with certain pairs of nicotinic acetylcholine receptor (nAChR) competitive antagonists. The mechanism for synergy has not been elucidated. We tested the hypothesis that synergy arises from a differential selectivity of antagonists for the two ligand binding sites on adult human nAChR.