Synergy Between Pairs of Competitive Antagonists at Adult Human Muscle Acetylcholine Receptors | Zendy

Man Liu | Zendy; James P. Dilger | Zendy

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Synergy Between Pairs of Competitive Antagonists at Adult Human Muscle Acetylcholine Receptors

Author(s) -

Man Liu,

James P. Dilger

Publication year - 2008

Publication title -

anesthesia and analgesia

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.404

H-Index - 201

eISSN - 1526-7598

pISSN - 0003-2999

DOI - 10.1213/ane.0b013e31817b4469

Subject(s) - medicine , pharmacology , competitive antagonist , antagonist , acetylcholine receptor , rocuronium , receptor , d tubocurarine , acetylcholine , neuromuscular blocking agents , nicotinic agonist , receptor antagonist , protein subunit , anesthesia , biochemistry , biology , propofol , gene

Synergistic neuromuscular blocking effects have been observed clinically with certain pairs of nicotinic acetylcholine receptor (nAChR) competitive antagonists. The mechanism for synergy has not been elucidated. We tested the hypothesis that synergy arises from a differential selectivity of antagonists for the two ligand binding sites on adult human nAChR.

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