Open AccessDexmedetomidine Enhances the Local Anesthetic Action of Lidocaine via an α-2A Adrenoceptor
Author(s) -
Tatsushi Yoshitomi,
Atsushi Kohjitani,
Shigeru Miyagawa,
Hitoshi Higuchi,
Mikio Shimada,
Takuya Miyawaki
Publication year - 2008
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.404
H-Index - 201
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/ane.0b013e318176be73
Subject(s) - dexmedetomidine , yohimbine , atipamezole , medicine , prazosin , clonidine , anesthesia , oxymetazoline , lidocaine , local anesthetic , alpha 2 adrenergic receptor , phenylephrine , alpha (finance) , agonist , pharmacology , antagonist , medetomidine , heart rate , surgery , receptor , blood pressure , construct validity , sedation , patient satisfaction
Clonidine, an alpha-2 adrenoceptor agonist, is a common adjunct in both central and peripheral blocks. Dexmedetomidine, a more selective alpha-2 adrenoceptor agonist, is also known to enhance central neural blockades. Its peripheral effect, however, has not been fully elucidated. Thus, we evaluated the effect of dexmedetomidine and other alpha-2 adrenoceptor agonists on the local anesthetic action of lidocaine at the periphery and explored the mechanism involved.