Dexmedetomidine Enhances the Local Anesthetic Action of Lidocaine via an α-2A Adrenoceptor | Zendy

Tatsushi Yoshitomi | Zendy; Atsushi Kohjitani | Zendy; Shigeru Maeda | Zendy; Hitoshi Higuchi | Zendy; Masahiko Shimada | Zendy; Takuya Miyawaki | Zendy

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Dexmedetomidine Enhances the Local Anesthetic Action of Lidocaine via an α-2A Adrenoceptor

Author(s) -

Tatsushi Yoshitomi,

Atsushi Kohjitani,

Shigeru Maeda,

Hitoshi Higuchi,

Masahiko Shimada,

Takuya Miyawaki

Publication year - 2008

Publication title -

anesthesia and analgesia

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.404

H-Index - 201

eISSN - 1526-7598

pISSN - 0003-2999

DOI - 10.1213/ane.0b013e318176be73

Subject(s) - dexmedetomidine , medicine , lidocaine , anesthesia , local anesthetic , anesthetic , pharmacology , sedation

Clonidine, an alpha-2 adrenoceptor agonist, is a common adjunct in both central and peripheral blocks. Dexmedetomidine, a more selective alpha-2 adrenoceptor agonist, is also known to enhance central neural blockades. Its peripheral effect, however, has not been fully elucidated. Thus, we evaluated the effect of dexmedetomidine and other alpha-2 adrenoceptor agonists on the local anesthetic action of lidocaine at the periphery and explored the mechanism involved.

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