The Effects of Aromatic Anesthetics on Dorsal Horn Neuronal Responses to Noxious Stimulation | Zendy

Aubrey Yao | Zendy; JongBun Kim | Zendy; Richard J. Atherley | Zendy; Steven L. Jinks | Zendy; E. Carstens | Zendy; Sean Shargh | Zendy; Alana Sulger | Zendy; Joseph F. Antognini | Zendy

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The Effects of Aromatic Anesthetics on Dorsal Horn Neuronal Responses to Noxious Stimulation

Author(s) -

Aubrey Yao,

JongBun Kim,

Richard J. Atherley,

Steven L. Jinks,

E. Carstens,

Sean Shargh,

Alana Sulger,

Joseph F. Antognini

Publication year - 2008

Publication title -

anesthesia and analgesia

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.404

H-Index - 201

eISSN - 1526-7598

pISSN - 0003-2999

DOI - 10.1213/ane.0b013e3181732ee3

Subject(s) - noxious stimulus , nociception , medicine , nmda receptor , stimulation , receptive field , neuroscience , anesthetic , anesthesia , spinal cord , pharmacology , receptor , biology , psychiatry

Gamma-aminobutyric acid type A receptor potentiation and/or N-methyl-d-aspartate (NMDA) receptor inhibition might explain the anesthetic properties of fluorinated aromatic compounds. We hypothesized that depression of dorsal horn neuronal responses to noxious stimulation would correlate with the magnitude of effect of benzene (BNZ), o-difluorobenzene, and hexafluorobenzene (HFB) on NMDA receptors.

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