The Effect of Clonidine Infusion on Distribution of Regional Cerebral Blood Flow in Volunteers | Zendy

Vincent Bonhomme | Zendy; Pierre Maquet | Zendy; Christophe Phillips | Zendy; Alain Plenevaux | Zendy; Pol Hans | Zendy; André Luxen | Zendy; Maurice Lamy | Zendy; Steven Laureys | Zendy

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The Effect of Clonidine Infusion on Distribution of Regional Cerebral Blood Flow in Volunteers

Author(s) -

Vincent Bonhomme,

Pierre Maquet,

Christophe Phillips,

Alain Plenevaux,

Pol Hans,

André Luxen,

Maurice Lamy,

Steven Laureys

Publication year - 2008

Publication title -

anesthesia and analgesia

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.404

H-Index - 201

eISSN - 1526-7598

pISSN - 0003-2999

DOI - 10.1213/ane.0b013e3181619685

Subject(s) - medicine , clonidine , anesthesia , cerebral blood flow , distribution (mathematics) , mathematical analysis , mathematics

Through their action on the locus coeruleus, alpha2-adrenoceptor agonists induce rapidly reversible sedation while partially preserving cognitive brain functions. Our goal in this observational study was to map brain regions whose activity is modified by clonidine infusion so as to better understand its loci of action, especially in relation to sedation.

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