Open AccessDopamine D3 Receptor Ser9Gly and Catechol-O-Methyltransferase Val158Met Polymorphisms and Acute Pain in Sickle Cell Disease
Author(s) -
Ellie H. Jhun,
Ying Hé,
Yingwei Yao,
Robert E. Molokie,
Diana J. Wilkie,
Zaijie Jim Wang
Publication year - 2014
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.404
H-Index - 201
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/ane.0000000000000382
Subject(s) - medicine , odds ratio , confidence interval , rs4680 , chronic pain , catechol o methyl transferase , genotype , physical therapy , genetics , biology , gene
Pain in sickle cell disease (SCD) is characterized by episodes of acute pain, primarily responsible for acute health care utilization, and persistent chronic pain. Pain severity and frequency vary significantly among patients with SCD. In this study, we investigated the possible contribution of monoamine gene polymorphisms to pain variation.